You apply the patch to your lower abdomen. You go about your morning. And 15 minutes later, something changes.

No medication. No side effects. Just a feeling of relaxation where it used to feel tight.

This is exactly what's happening in your body during that time.

1. How the patch penetrates your skin

The skin is not an impermeable barrier. It is a living organ, crisscrossed by hair follicles, glands, and capillaries. And certain molecules—the right ones, of the right size—can pass right through it.

This is known as transdermal delivery. The active ingredients in the patch are released gradually, absorbed by the skin, and pass directly into the local tissues without passing through the digestive system.

The result: the treatment is localized, targeted, and fast. Right where it hurts, and nowhere else.

2. What each ingredient does once absorbed

The Nané patch contains five natural active ingredients. Each one has a specific role.

CBD

It acts on the endocannabinoid receptors found in the smooth muscles of the uterus. It reduces pain signals and relaxes contractions. This is what accounts for the effect within 15 minutes.

Turmeric

It is a powerful natural anti-inflammatory. It inhibits prostaglandins, the very molecules responsible for cramps. When applied topically, it acts directly on the source of the inflammation.

Menthol

It creates an immediate cooling sensation that activates the cold receptors in the skin. These receptors block pain signals: it’s the same mechanism as a warming balm, but in a natural, non-irritating form.

Green tea

Rich in antioxidants, it reduces oxidative stress in tissues and supports turmeric's anti-inflammatory effects over time.

The pomegranate

It contains polyphenols that regulate hormones and reduce the intensity of uterine contractions. It works more deeply, affecting the hormonal cycle.

3. The timeline: what happens from midnight to midnight

Within 0 to 15 minutes, the CBD and menthol are absorbed first. Pain signals decrease, and muscles relax.

Within 15 minutes to 2 hours, turmeric and green tea begin to take effect. The local inflammation starts to subside.

For 2 to 24 hours, pomegranate and the other active ingredients continue to work deep within the skin. The patch lasts all day, is waterproof, and can be worn under your clothes.

Key takeaways

The patch does not mask the pain. It acts on the mechanisms that cause it: muscle contractions, inflammation, and nerve signals.

That's why it works best when taken early, at the first sign of symptoms. Not when the pain has already set in.

Discover the Nané patch: 5 natural ingredients, effective for 24 hours.

Sources

  • INSERM: Transdermal diffusion and cutaneous absorption
  • Journal of Pain Research: CBD and Menstrual Pain
  • Phytotherapy Research: Turmeric and Prostaglandins
  • European Journal of Pharmacology: Menthol and TRPM8 receptors